the traditional methods can not reach or clean area, crack and crevice. Once the cotton picking up residue, can not let it fall out. Cotton swab sampling is probably the most widely used in the cleaning validation sampling technique. This is the most important in the evaluation of cleaning validation process. Cotton swabs and physical characteristics of the surface of the substrate and physical cleaning validation program in physical movement has played a certain role. Chemical process including the use of wet cotton swab for analysis object samples from the substrate surface, and then from the cotton swab in the analytes were extracted 

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